Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry

Martin J. Zuckermann, Christopher N. Angstmann, Regina Schmitt, Gerhard A. Blab, Elizabeth H.C. Bromley, Nancy R. Forde, Heiner Linke, Paul M.G. Curmi: Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry. In: New Journal of Phyiscs, 17 , pp. 055017, 2015.

Abstract

The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of ~18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker's momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet.

BibTeX (Download)

@article{Zuckermann2015,
title = {Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry},
author = {Martin J. Zuckermann and Christopher N. Angstmann and Regina Schmitt and Gerhard A. Blab and Elizabeth H.C. Bromley and Nancy R. Forde and Heiner Linke and Paul M.G. Curmi},
url = {http://iopscience.iop.org/1367-2630/17/5/055017/},
doi = {10.1088/1367-2630/17/5/055017},
year  = {2015},
date = {2015-05-05},
journal = {New Journal of Phyiscs},
volume = {17},
pages = {055017},
abstract = {The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of ~18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker's momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet.},
keywords = {Linear Motors, Thermodynamics},
pubstate = {published},
tppubtype = {article}
}